By Philippe Derreumaux
Alzheimer's affliction is the most typical type of senile dementia, affecting greater than 24 million humans around the world. it's characterized pathologically by way of abnormally excessive degrees of neurofibrillary tangles caused by the buildup of tau protein in lifeless and demise neurons, and through increased numbers of senile plaques within the cortex and hippocampus of the mind. the main component to senile plaques is a small protein of 39–43 amino acids referred to as amyloid-β (Aβ). to date, no therapy has been proven to sluggish the development of sporadic and familial Alzheimer's disease.
A huge physique of proof issues, notwithstanding, to the early Aβ-formed oligomers because the fundamental poisonous species in Alzheimer's disorder. a strong method for constructing pharmaceutical remedies opposed to Alzheimer's is to clarify the pathways of oligomer formation and be certain the constructions of the poisonous aggregates.
This ebook presents a breathtaking view throughout contemporary in vitro and in vivo reviews in addition to cutting-edge machine simulations, designed to extend the readers' knowing of Aβ oligomerisation and fibril formation. whilst, the ebook delves into the pathogenesis of familial and sporadic Alzheimer's affliction on the atomic point of detail.
Written via best authors of their respective fields, this e-book can be useful to all scientists engaged on Alzheimer's disease.
Readership: basic public, PhD scholars, postdocs, in addition to all scientists operating within the following fields: Alzheimer's disorder, amyloids, neuroscience, oligomers, protofibrils, fibrils, toxicity, buildings, dynamics, kinetics, thermodynamics, all-atom and coarse grained simulations, biophysics, reminiscence, studying, transgenic mouse versions, steel ions, membrane, nanoparticles, computational chemistry, drug layout and bioinformatics.
Read Online or Download Alzheimer's Disease: Insights into Low Molecular Weight and Cytotoxic Aggregates from In Vitro and Computer Experiments:Molecular Basis of Amyloid-Beta ... (Molecular Medicine and Medicinal Chemistry) PDF
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Additional info for Alzheimer's Disease: Insights into Low Molecular Weight and Cytotoxic Aggregates from In Vitro and Computer Experiments:Molecular Basis of Amyloid-Beta ... (Molecular Medicine and Medicinal Chemistry)
Alzheimer's Disease: Insights into Low Molecular Weight and Cytotoxic Aggregates from In Vitro and Computer Experiments:Molecular Basis of Amyloid-Beta ... (Molecular Medicine and Medicinal Chemistry) by Philippe Derreumaux
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